uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Aggressive Behavior, Related Conduct Problems, and Variation in Genes Affecting Dopamine Turnover
Show others and affiliations
2010 (English)In: Aggressive Behavior, ISSN 0096-140X, E-ISSN 1098-2337, Vol. 36, no 3, 158-176 p.Article in journal (Refereed) Published
Abstract [en]

A number of dopamine-related genes have been implicated in the etiology of violent behavior and conduct problems. Of these genes, the ones that code for the enzymes that influence the turnover of dopamine (DA) have received the most attention. In this study, we investigated 12 genetic polymorphisms in four genes involved with DA functioning (COMT, MAOA and MAOB, and D beta H in 179 incarcerated male Russian adolescents and two groups of matched controls: boys without criminal records referred to by their teachers as (a) "troubled-behavior-free" boys, n = 182; and (b) "troubled-behavior" boys, n = 60. The participants were classified as (1) being incarcerated or not, (2) having the DSM-IV diagnosis of conduct disorder (CD) or not, and (3) having committed violent or nonviolent crimes (for the incarcerated individuals only). The findings indicate that, although no single genetic variant in any of the four genes differentiated individuals in the investigated groups, various linear combinations (i.e., haplotypes) and nonlinear combinations (i.e., interactions between variants within and across genes) of genetic variants resulted in informative and robust classifications for two of the three groupings. These combinations of genetic variants differentiated individuals in incarceration vs. nonincarcerated and CD vs. no-CD groups; no informative combinations were established consistently for the grouping by crime within the incarcerated individuals. This study underscores the importance of considering multiple rather than single markers within candidate genes and their additive and interactive combinations, both with themselves and with nongenetic indicators, while attempting to understand the genetic background of such complex behaviors as serious conduct problems.

Place, publisher, year, edition, pages
2010. Vol. 36, no 3, 158-176 p.
Keyword [en]
aggressive behavior, conduct problems, dopamine-related genes, MDR, juvenile delinquents
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-136987DOI: 10.1002/ab.20339ISI: 000276782800002OAI: oai:DiVA.org:uu-136987DiVA: diva2:377794
Available from: 2010-12-14 Created: 2010-12-14 Last updated: 2016-02-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Ruchkin, Vladislav V.
By organisation
Department of Neuroscience
In the same journal
Aggressive Behavior
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 266 hits
ReferencesLink to record
Permanent link

Direct link