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Fatty acid oxidation and isoprostanes: oxidative strain and oxidative stress
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Oxidative Stress and Inflammation.
2010 (English)In: Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, E-ISSN 1532-2823, Vol. 82, no 4-6, 219-225 p.Article in journal (Refereed) Published
Abstract [en]

Oxidative stress is implicated as one of the key causes underlying many diseases. Free radicals are important constituents of basal physiology. Assessment of free radicals or the end products of their action has proved to be difficult. Consequently, authentication of the contribution of free radicals to physiology and pathology has usually been equivocal. Isoprostanes are biosynthesized in vivo, predominantly through free radical attack on arachidonic acid and are now regarded as robust biomarkers of oxidative stress in vivo. Isoprostanes are associated with many human diseases, and their concentration is altered over the course of normal human pregnancy, but their (patho)physiological roles have not yet been clearly defined. Measurement of F-2-isoprostanes in body fluids could offer a unique analytical opportunity to study the role of free radicals in physiology and pathophysiology in order to comprehend both oxidative strain and oxidative stress.


Place, publisher, year, edition, pages
2010. Vol. 82, no 4-6, 219-225 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-136887DOI: 10.1016/j.plefa.2010.02.031ISI: 000277967800012OAI: oai:DiVA.org:uu-136887DiVA: diva2:377848
Available from: 2010-12-15 Created: 2010-12-14 Last updated: 2010-12-15Bibliographically approved

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Oxidative Stress and Inflammation
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Prostaglandins, Leukotrienes and Essential Fatty Acids
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