Antisecretory factor-inducing therapy improves the clinical outcome in patients with Meniere's disease
2010 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 130, no 2, 223-227 p.Article in journal (Refereed) Published
Conclusion: Intake of antisecretory factor (AF)-inducing SPC-flakes (R) significantly reduced vertigo in patients suffering from Meniere's disease (MD). The positive effect may be due to a modulation of the transport of water and ions in the endolymphatic space. Objective: To evaluate the effects of a 3-month treatment period with SPC-flakes (R) in patients suffering from MD. Patients and methods: A prospective, double-blind, placebo-controlled study was performed. A total of 51 adult patients with MD were included in the study: 27 subjects treated with SPC-flakes (R) and 24 subjects with control cereals. The patients received SPC-flakes (R) or control cereals (I g per kg body weight per 24 h in two servings) for 3 months. Otoneurological examinations were carried out before and after this period. Results: The severity of MD was classified according to the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) grading system. Fourteen of the 27 patients randomized to intake of the AF-inducing SPC-flakes (R) reported decreased vertigo, compared with 2 of 24 in the control group (p < 0.001). No consistent change in the otoneurological examinations could be demonstrated in any of the groups of patients.
Place, publisher, year, edition, pages
2010. Vol. 130, no 2, 223-227 p.
Antisecretory factor, specially processed cereals, endolymph homeostasis, vertigo
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-136707DOI: 10.3109/00016480903022842ISI: 000275219000004PubMedID: 19479454OAI: oai:DiVA.org:uu-136707DiVA: diva2:377885