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Antisecretory factor-inducing therapy improves the clinical outcome in patients with Meniere's disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2010 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 130, no 2, 223-227 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion: Intake of antisecretory factor (AF)-inducing SPC-flakes (R) significantly reduced vertigo in patients suffering from Meniere's disease (MD). The positive effect may be due to a modulation of the transport of water and ions in the endolymphatic space. Objective: To evaluate the effects of a 3-month treatment period with SPC-flakes (R) in patients suffering from MD. Patients and methods: A prospective, double-blind, placebo-controlled study was performed. A total of 51 adult patients with MD were included in the study: 27 subjects treated with SPC-flakes (R) and 24 subjects with control cereals. The patients received SPC-flakes (R) or control cereals (I g per kg body weight per 24 h in two servings) for 3 months. Otoneurological examinations were carried out before and after this period. Results: The severity of MD was classified according to the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) grading system. Fourteen of the 27 patients randomized to intake of the AF-inducing SPC-flakes (R) reported decreased vertigo, compared with 2 of 24 in the control group (p < 0.001). No consistent change in the otoneurological examinations could be demonstrated in any of the groups of patients.

Place, publisher, year, edition, pages
2010. Vol. 130, no 2, 223-227 p.
Keyword [en]
Antisecretory factor, specially processed cereals, endolymph homeostasis, vertigo
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-136707DOI: 10.3109/00016480903022842ISI: 000275219000004PubMedID: 19479454OAI: oai:DiVA.org:uu-136707DiVA: diva2:377885
Available from: 2010-12-15 Created: 2010-12-14 Last updated: 2013-08-12Bibliographically approved

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