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A New Antioxidant Compound H-290/51 Attenuates Nanoparticle Induced Neurotoxicity and Enhances Neurorepair in Hyperthermia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
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2010 (English)In: Brain Edema XIV / [ed] Zbigniew Czernicki et al., Vienna: Springer , 2010, Vol. 106, 351-357 p.Conference paper (Refereed)
Abstract [en]

Previous reports from our laboratory show that animals treated with engineered nanoparticles derived from metals for 1 week and subjected to hyperthermia showed enhanced neurotoxicity in teens of blood-brain barrier (BBB) disruption, brain edema formation and cell injury. It appears that nano-particle induced enhanced oxidative stress leads to increased lipid peroxidation and over-production of hydroxyl radicals are responsible for exacerbation of neurotoxicity in hyperthermia. Therefore, in this investigation, rats (after 1 week administration of Ag or Cu nanoparticles) were treated with a new antioxidant compound H-290/51 (an inhibitor of lipid peroxidation, 50 mg/kg, p.o.) before subjecting them to hyperthermia. One group of nanoparticle treated rat received H-290/51 and were kept at room temperature for comparison. Our results show that H-290/51 significantly attenuated heat stress induced BBB impairment, brain edema formation and neurotoxicity in nanoparticle treated rats. However, no significant diminution of nanoparticle induced BBB breakdown, or neurotoxicity was observed in H-290/51 treated rats kept at room temperature. These observations suggest that nanoparticles aggravate oxidative stress following hyperthermia leading to exacerbation of neurotoxicity through oxidative stress-related mechanisms, not reported earlier.

Place, publisher, year, edition, pages
Vienna: Springer , 2010. Vol. 106, 351-357 p.
, Acta Neurochirurgica Supplementum, ISSN 0065-1419 ; 106/9
Keyword [en]
Nanoparticles, silver, copper, hyperthermia, blood-brain barrier, brain edema, oxidative stress, H-290/51, neurotoxicity, neuroprotection
National Category
Anesthesiology and Intensive Care
URN: urn:nbn:se:uu:diva-137496DOI: 10.1007/978-3-211-98811-4_64ISI: 000274867500064ISBN: 978-3-211-98758-2ISBN: 978-3-211-98811-4OAI: oai:DiVA.org:uu-137496DiVA: diva2:378240
14th International Symposium on Brain Edema and Brain Tissue Injury Warsaw, POLAND, JUN 11-14, 2008
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2012-03-15Bibliographically approved

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Sharma, Hari Shanker
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