A New Antioxidant Compound H-290/51 Attenuates Nanoparticle Induced Neurotoxicity and Enhances Neurorepair in Hyperthermia
2010 (English)In: Brain Edema XIV / [ed] Zbigniew Czernicki et al., Vienna: Springer , 2010, Vol. 106, 351-357 p.Conference paper (Refereed)
Previous reports from our laboratory show that animals treated with engineered nanoparticles derived from metals for 1 week and subjected to hyperthermia showed enhanced neurotoxicity in teens of blood-brain barrier (BBB) disruption, brain edema formation and cell injury. It appears that nano-particle induced enhanced oxidative stress leads to increased lipid peroxidation and over-production of hydroxyl radicals are responsible for exacerbation of neurotoxicity in hyperthermia. Therefore, in this investigation, rats (after 1 week administration of Ag or Cu nanoparticles) were treated with a new antioxidant compound H-290/51 (an inhibitor of lipid peroxidation, 50 mg/kg, p.o.) before subjecting them to hyperthermia. One group of nanoparticle treated rat received H-290/51 and were kept at room temperature for comparison. Our results show that H-290/51 significantly attenuated heat stress induced BBB impairment, brain edema formation and neurotoxicity in nanoparticle treated rats. However, no significant diminution of nanoparticle induced BBB breakdown, or neurotoxicity was observed in H-290/51 treated rats kept at room temperature. These observations suggest that nanoparticles aggravate oxidative stress following hyperthermia leading to exacerbation of neurotoxicity through oxidative stress-related mechanisms, not reported earlier.
Place, publisher, year, edition, pages
Vienna: Springer , 2010. Vol. 106, 351-357 p.
, Acta Neurochirurgica Supplementum, ISSN 0065-1419 ; 106/9
Nanoparticles, silver, copper, hyperthermia, blood-brain barrier, brain edema, oxidative stress, H-290/51, neurotoxicity, neuroprotection
Anesthesiology and Intensive Care
IdentifiersURN: urn:nbn:se:uu:diva-137496DOI: 10.1007/978-3-211-98811-4_64ISI: 000274867500064ISBN: 978-3-211-98758-2ISBN: 978-3-211-98811-4OAI: oai:DiVA.org:uu-137496DiVA: diva2:378240
14th International Symposium on Brain Edema and Brain Tissue Injury Warsaw, POLAND, JUN 11-14, 2008