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Influence of Nanoparticles on Blood-Brain Barrier Permeability and Brain Edema Formation in Rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
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2010 (English)In: Brain Edema XIV / [ed] Zbigniew Czernicki et al., Vienna: Springer , 2010, Vol. 106, 359-364 p.Conference paper (Refereed)
Abstract [en]

Nanoparticles are small sized (1-100 nm) particles derived from transition metals, silver, copper, aluminum, silicon, carbon and metal oxides that can easily cross the blood-brain barrier (BBB) and/or produce damage to the barrier integrity by altering endothelial cell membrane permeability. However, the influence of nanoparticles on BBB integrity is still not well-known. In this investigation, effect of nanoparticles derived from Ag, Al and Cu (50-60 nm) on BBB permeability in relation to brain edema formation was examined in a rat model. Intravenous (30 mg/kg), intraperitoneal (50 mg/kg) or intracerebral (20 mu g in 10 mu L) administration of Ag, Cu or AI nanoparticles disrupted the BBB function to Evans blue albumin (EBA) and radioiodine in rats 24 h after administration and induced brain edema formation. The leakage of Evans blue dye was observed largely in the ventral surface of brain and in the proximal frontal cortex. The dorsal surfaces of cerebellum showed mild to moderate EBA staining. These effects were most pronounced in animals that received Ag or Cu nanoparticles compared to Al nanoparticles through intravenous routes. These observations are the first to suggest that nanoparticles can induce brain edema formation by influencing BBB breakdown in vivo.

Place, publisher, year, edition, pages
Vienna: Springer , 2010. Vol. 106, 359-364 p.
, Acta Neurochirurgica Supplementum, ISSN 0065-1419 ; 106/9
Keyword [en]
Nanoparticles, silver, copper, aluminum, blood-brain barrier, brain edema, Evans blue, radioiodine
National Category
Anesthesiology and Intensive Care
URN: urn:nbn:se:uu:diva-137497DOI: 10.1007/978-3-211-98811-4_65ISI: 000274867500065ISBN: 978-3-211-98758-2ISBN: 978-3-211-98811-4OAI: oai:DiVA.org:uu-137497DiVA: diva2:378250
14th International Symposium on Brain Edema and Brain Tissue Injury Warsaw, POLAND, JUN 11-14, 2008
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2012-03-15Bibliographically approved

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Sharma, Hari Shanker
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