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Nanowired-Drug Delivery Enhances Neuroprotective Efficacy of Compounds and Reduces Spinal Cord Edema Formation and Improves Functional Outcome Following Spinal Cord Injury in the Rat
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
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2010 (English)In: Brain Edema XIV / [ed] Zbigniew Czernicki et, Vienna: Springer , 2010, Vol. 106, 343-350 p.Conference paper (Refereed)
Abstract [en]

The possibility that drugs attached to nanowires enhance their therapeutic efficacy was examined in a rat model of spinal cord injury (SCI). Three Acure compounds AP-173, AP-713 and AP-364 were tagged with TiO2-based nanowires (50-60 nm) and applied over the traumatized cord either 5 or 60 min after SCI in rats produced by a longitudinal incision into the right dorsal horn of the T10-11 segments under equithesin anaesthesia. Normal compounds were used for comparison. After 5 h SCI, behavioral outcome, blood-spinal cord barrier (BSCB) permeability, edema formation and cell injury were examined. Topical application of nanowired compound AP-713 (10 mu g in 20 mu L) when applied either 5 or 60 min after injury markedly attenuated behavioral dysfunction at 2-3 h after SCI and reduces BSCB disruption, edema formation and cord pathology at 5 h compared to other compounds. Whereas normal compounds applied at 5 min after injury (but not after 60 min) had some significant but less beneficial effects compared to their nanowired combinations. On the other hand, nanowires alone did not influence spinal cord pathology or motor function after SCI. Taken together, our results indicate that the nanowired-drug-delivery enhances the neuroprotective efficacy of drugs in SCI and reduces functional outcome compared to normal compounds even applied at a later stage following trauma, not reported earlier.

Place, publisher, year, edition, pages
Vienna: Springer , 2010. Vol. 106, 343-350 p.
, Acta Neurochirurgica Supplementum, ISSN 0065-1419 ; 106/9
Keyword [en]
Nanoparticles, nanowire, titanium dioxide, spinal cord injury, AP-713, Blood-spinal cord barrier, spinal cord edema, Tarlov scale, motor function
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-137495DOI: 10.1007/978-3-211-98811-4_63ISI: 000274867500063ISBN: 978-3-211-98758-2ISBN: 978-3-211-98811-4OAI: oai:DiVA.org:uu-137495DiVA: diva2:378264
14th International Symposium on Brain Edema and Brain Tissue Injury Warsaw, POLAND, JUN 11-14, 2008
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2012-03-15Bibliographically approved

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Sharma, Hari Shanker
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