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Cerebrolysin Attenuates Blood-Brain Barrier and Brain Pathology Following Whole Body Hyperthermia in the Rat
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2010 (English)In: Brain Edema XIV / [ed] Zbigniew Czernicki et al., Vienna: Springer , 2010, Vol. 106, 321-325 p.Conference paper, Published paper (Refereed)
Abstract [en]

The possibility that Cerebrolysin, a mixture of several neurotrophic factors, has some neuroprotective effects on whole body hyperthermia (WBH) induced breakdown of the blood-brain barrier (BBB), blood-CSF barrier (BCSFB), brain edema formation and neuropathology were examined in a rat model. Rats subjected to a 4 h heat stress at 38 C in a biological oxygen demand (BOD) incubator exhibited profound increases in BBB and BCSFB permeability to Evans blue and radioiodine tracers compared to controls. Hippocampus, caudate nucleus, thalamus and hypothalamus exhibited pronounced increase in water content and brain pathology following 4 h heat stress. Pretreatment with Cerebrolysin (1, 2 or 5 mL/kg i.v.) 24 h before WBH significantly attenuated breakdown of the BBB or BCSFB and brain edema formation. This effect was dose dependent. Interestingly, the cell and tissue injury following WBH in cerebrolysin-treated groups were also considerably reduced. These novel observations suggest that cerebrolysin can attenuate WBH induced BBB and BCSFB damage resulting in neuroprotection.

Place, publisher, year, edition, pages
Vienna: Springer , 2010. Vol. 106, 321-325 p.
Series
Acta Neurochirurgica Supplementum, ISSN 0065-1419 ; 106/8
Keyword [en]
Cerebrolysin, whole body hyperthermia, brain edema, blood-brain barrier, blood-CSF barrier, brain pathology, neuroprotection
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-137493DOI: 10.1007/978-3-211-98811-4_60ISI: 000274867500060ISBN: 978-3-211-98758-2 (print)ISBN: 978-3-211-98811-4 (print)OAI: oai:DiVA.org:uu-137493DiVA: diva2:378270
Conference
14th International Symposium on Brain Edema and Brain Tissue Injury Warsaw, POLAND, JUN 11-14, 2008
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2012-03-15Bibliographically approved

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Sharma, Hari Shanker

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