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Chronic Hypertension Aggravates Heat Stress-Induced Brain Damage: Possible Neuroprotection by Cerebrolysin
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2010 (English)In: Brain Edema XIV / [ed] Zbigniew Czernicki et al., Vienna: Springer , 2010, Vol. 106, 327-333 p.Conference paper (Refereed)
Abstract [en]

Whole body hyperthermia (WBH) aggravates brain edema formation and cell damage in chronic hypertensive rats compared with normotensive animals. In this investigation, we examined the influence of cerebrolysin on WBH-induced edema formation and brain pathology in hypertensive and normotensive rats. Rats subjected to 4 h WBH at 38 C in a biological oxygen demand (BOD) incubator showed breakdown of the blood-brain barrier (BBB), reduced cerebral blood flow (CBF), edema formation and cell injuries in several parts of the brain. These effects were further aggravated in chronic hypertensive rats (two-kidney one clip model (2K1C), for 4 weeks) subjected to WBH. Pretreatment with cerebrolysin (5 mL/kg, 24 h and 30 min before heat stress) markedly attenuated the BBB dysfunction and brain pathology in normal animals. However, in hypertensive animals, a high dose of cerebrolysin (10 mL/kg, 24 h and 30 min before heat stress) was needed to attenuate WBH-induced BBB dysfunction and brain pathology. These observations indicate that heat stress could affect differently in normal and hypertensive conditions. Furthermore, our results suggest that patients suffering from various chronic cardiovascular diseases may respond differently to hyperthermia and to neuroprotective drugs, e.g., cerebrolysin not reported earlier.

Place, publisher, year, edition, pages
Vienna: Springer , 2010. Vol. 106, 327-333 p.
, Acta Neurochirurgica Supplementum, ISSN 0065-1419 ; 106/8
Keyword [en]
Cerebrolysin, whole body hyperthermia, hypertensive rats, brain edema, brain pathology, cerebral blood flow
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-137494DOI: 10.1007/978-3-211-98811-4_61ISI: 000274867500061ISBN: 978-3-211-98758-2ISBN: 978-3-211-98811-4OAI: oai:DiVA.org:uu-137494DiVA: diva2:378280
14th International Symposium on Brain Edema and Brain Tissue Injury Warsaw, POLAND, JUN 11-14, 2008
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2010-12-15Bibliographically approved

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