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Selected Combination of Neurotrophins Potentiate Neuroprotection and Functional Recovery Following Spinal Cord Injury in the Rat
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2010 (English)In: Brain Edema XIV / [ed] Zbigniew Czernicki et al., Vienna: Springer , 2010, Vol. 106, 295-300 p.Conference paper (Refereed)
Abstract [en]

The possibility that a combination of neurotrophins induces long-lasting neuroprotection of the cord following spinal cord injury (SCI) was examined in a rat model. The SCI was performed by making a unilateral incision into the right dorsal horn of the T10-11 segments and the animals were allowed to survive 5 h after trauma. Different combination of neurotrophins, i.e., BDNF in combination with GDNF, NT-3, or NGF was applied topically over the traumatized spinal cord and motor dysfunction, blood-spinal cord barrier (BSCB) breakdown, edema formation, and cell injury were examined. Topical application of BDNF in combination with GDNF and NGF 30 min (but not 60 or 90 min) at high concentrations (0.5 mu g each) after SCI significantly improved motor function and reduced BSCB breakdown, edema formation, and cell injury at 5 h. However, concurrent application of BDNF, IGF-1, and GDNF (but not with NT-3 or NGF) even 60 or 90 min after trauma induced a significant reduction in motor dysfunction and spinal cord pathology. These observations suggest that a combination of neurotrophins may have added therapeutic value in the treatment of SCI, not reorted earlier.

Place, publisher, year, edition, pages
Vienna: Springer , 2010. Vol. 106, 295-300 p.
, Acta Neurochirurgica Supplementum, ISSN 0065-1419 ; 106/8
Keyword [en]
Spinal cord injury, BDNF, IGF-1, GDNF, blood-spinal cord barrier, edema, motor function, spinal cord pathology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-137491DOI: 10.1007/978-3-211-98811-4_55ISI: 000274867500055ISBN: 978-3-211-98758-2ISBN: 978-3-211-98811-4OAI: oai:DiVA.org:uu-137491DiVA: diva2:378288
14th International Symposium on Brain Edema and Brain Tissue Injury Warsaw, POLAND, JUN 11-14, 2008
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2012-03-15Bibliographically approved

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