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Alterations in Blood-Brain Barrier Function and Brain Pathology by Morphine in the Rat. Neuroprotective Effects of Antioxidant H-290/51
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2010 (English)In: Brain Edema XIV / [ed] Zbigniew Czernicki et al., Vienna: Springer , 2010, Vol. 106, 61-66 p.Conference paper (Refereed)
Abstract [en]

The possibility that stress associated with morphine administration or withdrawal will influence the blood-brain barrier (BBB) dysfunction, brain edema formation and brain pathology was examined in a rat model. Repeated daily administration of morphine (10 mg/kg, i.p.) resulted in drug dependence in rats on the 6th day and onwards. The BBB permeability to Evans blue albumin (EBA) and radioiodine ([131])Iodine did not alter during morphine dependence up to the 12th day. On the other hand, spontaneous withdrawal of morphine on day 1 resulted in profound stress symptoms and breakdown of the BBB to protein tracers in several brain regions. This increase in BBB to protein tracers was most pronounced on the 2nd day of morphine withdrawal. These rats also exhibited marked brain edema and abnormal neuronal and glial cell responses. Pretreatment with an antioxidant H-290/51 markedly attenuated the BBB dysfunction, brain edema formation and brain pathology during morphine withdrawal phases. These observations suggest that psychostimulants and associated oxidative stress are capable to induce brain pathology through modifying the BBB function.

Place, publisher, year, edition, pages
Vienna: Springer , 2010. Vol. 106, 61-66 p.
, Acta Neurochirurgica Supplementum, ISSN 0065-1419 ; 106/2
Keyword [en]
Morphine withdrawal, brain edema, blood-brain barrier, oxidative stress, H-290/51, glial fibrillary acidic protein, neuronal damage, neuroprotection
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-137490DOI: 10.1007/978-3-211-98811-4_10ISI: 000274867500010ISBN: 978-3-211-98758-2ISBN: 978-3-211-98811-4OAI: oai:DiVA.org:uu-137490DiVA: diva2:378311
14th International Symposium on Brain Edema and Brain Tissue Injury Warsaw, POLAND, JUN 11-14, 2008
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2012-03-15Bibliographically approved

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Sharma, Hari Shanker
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