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Short cut to 1,2,3-triazole-based p38 MAP kinase inhibitors via [3+2]-cycloaddition chemistry
University of Gothenburg.
University of Gothenburg.
University of Gothenburg.
University of Gothenburg.
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2009 (English)In: New Journal of Chemistry, Vol. 33, no 5, 1010-1016 p.Article in journal (Refereed) Published
Abstract [en]

A series of 4,5-substituted 1,2,3-triazoles was synthesised via Cu(I)-catalysed azide-alkyne 1,3-dipolar [2 + 3]-cycloaddition reactions followed by a Suzuki coupling. The 1,2,3-triazoles were evaluated as inhibitors of the p38 alpha MAP kinase, showing IC50 values in the high nanomolar range.

Place, publisher, year, edition, pages
2009. Vol. 33, no 5, 1010-1016 p.
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URN: urn:nbn:se:uu:diva-137507DOI: 10.1039/b818909aOAI: oai:DiVA.org:uu-137507DiVA: diva2:378398
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internal-pdf://Dinér-2009-Short cut to 1,2,3-t-2084848384/Dinér-2009-Short cut to 1,2,3-t.pdfAvailable from: 2010-12-15 Created: 2010-12-15 Last updated: 2011-01-07

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