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Short cut to 1,2,3-triazole-based p38 MAP kinase inhibitors via [3+2]-cycloaddition chemistry
University of Gothenburg.
University of Gothenburg.
University of Gothenburg.
University of Gothenburg.
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2009 (English)In: New Journal of Chemistry, Vol. 33, no 5, p. 1010-1016Article in journal (Refereed) Published
Abstract [en]

A series of 4,5-substituted 1,2,3-triazoles was synthesised via Cu(I)-catalysed azide-alkyne 1,3-dipolar [2 + 3]-cycloaddition reactions followed by a Suzuki coupling. The 1,2,3-triazoles were evaluated as inhibitors of the p38 alpha MAP kinase, showing IC50 values in the high nanomolar range.

Place, publisher, year, edition, pages
2009. Vol. 33, no 5, p. 1010-1016
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URN: urn:nbn:se:uu:diva-137507DOI: 10.1039/b818909aOAI: oai:DiVA.org:uu-137507DiVA, id: diva2:378398
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internal-pdf://Dinér-2009-Short cut to 1,2,3-t-2084848384/Dinér-2009-Short cut to 1,2,3-t.pdfAvailable from: 2010-12-15 Created: 2010-12-15 Last updated: 2011-01-07

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