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Bile acids: short and long term effects in the intestine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
2010 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, Vol. 45, no 6, 645-664 p.Article, review/survey (Refereed) Published
Abstract [en]

Bile acids have secretory, motility and antimicrobial effects in the intestine. In patients with bile acid malabsorption the amount of primary bile acids in the colon is increased compared to healthy controls. Deoxycholic acid is affecting the intestinal smooth muscle activity. Chenodeoxycholic acid has the highest potency to affect intestinal secretion. Litocholic acid has little effect in the lumen of intestine compared to both deoxycholic acid and chenodeoxycholic acid. There is no firm evidence that clinically relevant concentrations of bile acids induce colon cancer. Alterations in bile acid metabolism may be involved in the pathophysiology of constipation.

Place, publisher, year, edition, pages
2010. Vol. 45, no 6, 645-664 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-137742DOI: 10.3109/00365521003702734ISI: 000277365200003OAI: oai:DiVA.org:uu-137742DiVA: diva2:378533
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2010-12-15Bibliographically approved

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