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Nicotine hapten structure, antibody selectivity and effect relationships: Results from a nicotine vaccine screening procedure
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
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2010 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 28, no 10, 2161-2168 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to synthesise and screen a set of novel nicotine hapten immunogens used for the treatment of nicotine dependence. In the screening process we studied the amount of antibodies generated and their selectivity, using ELISA techniques, and their effects on nicotine-induced dopamine release in the NAC(shell) of the rat, assessed by in vivo voltammetry. We conclude that even small changes such as the linker attachment on the nicotine molecule as well as the structure of the linker may greatly influence the selectivity of the antibodies and the central neurobiological effects of nicotine that are considered critical for its dependence producing properties. (C) 2010 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2010. Vol. 28, no 10, 2161-2168 p.
Keyword [en]
Nicotine dependence, Nicotine vaccine, Nicotine hapten
National Category
Pharmaceutical Sciences Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-137631DOI: 10.1016/j.vaccine.2009.12.051ISI: 000275933600003OAI: oai:DiVA.org:uu-137631DiVA: diva2:378566
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2017-12-11Bibliographically approved

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