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Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.ORCID iD: 0000-0003-2789-6276
2010 (English)In: Cardiovascular Research, ISSN 0008-6363, E-ISSN 1755-3245, ISSN 20472565, Vol. 87, no 2, 211-217 p.Article, review/survey (Refereed) Published
Abstract [en]

This review will summarize current knowledge on the role of the extracellular matrix (ECM) in general and on the interstitial fluid pressure (P-if) in particular with regard to their importance in transcapillary exchange. The fluid volume in the interstitial space is normally regulated within narrow limits by automatic re-adjustment of the interstitial hydrostatic and colloid osmotic pressures in response to perturbations in capillary filtration and by the lymphatics. Contrary to this commonly accepted view, P-if can become an active force and create a fluid flux across the capillaries in several inflammatory reactions and trauma situations rather than limit the changes occurring. The molecular mechanisms involved in the lowering of P-if include the release of cellular tension exerted on the collagen and microfibril networks in the connective tissue via the collagen-binding beta(1)-integrins, thereby allowing the glycosaminoglycan ground substance, which is normally underhydrated, to expand and take up fluid. Several growth factors and cytokines, including the platelet-derived growth factor BB, are able to reverse a lowering of P-if and restore the normal compaction of the ECM. The magnitude of the lowering of P-if varies with the inflammatory response. In several inflammatory reactions, a lowering of P-if to -5 to -10 mmHg is seen, which will increase capillary filtration by 10-20 times since the normal capillary filtration pressure is usually 0.5-1 mmHg (skin and skeletal muscle). Unless this lowering of P-if is taken into account, the enhanced solute flux resulting from an inflammatory response will be ascribed to an increased capillary permeability.

Place, publisher, year, edition, pages
2010. Vol. 87, no 2, 211-217 p.
Keyword [en]
Connective tissue, beta-Integrin receptors, Glycosaminoglycans, Inflammation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-137727DOI: 10.1093/cvr/cvq143ISI: 000279470700003PubMedID: 20472565OAI: oai:DiVA.org:uu-137727DiVA: diva2:378645
Available from: 2010-12-16 Created: 2010-12-15 Last updated: 2017-12-11Bibliographically approved

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Rubin, Kristofer

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