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Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2010 (English)In: Progress in molecular biology and translational science, ISSN 1877-1173, Vol. 93, 35-58 p.Article, review/survey (Refereed) Published
Abstract [en]

Ndsts (N-deacetylase/N-sulfotransferases) are enzymes responsible for N-sulfation during heparan sulfate (HS) and heparin biosynthesis. In this review, basic features of the Ndst1 enzyme are covered and a brief description of HS biosynthesis and its regulation is presented. Effects of Ndst1 deficiency on embryonic development are described. These include immature lungs, craniofacial dysplasia and eye developmental defects, branching defect during lacrimal gland development, delayed mineralization of the skeleton, and reduced pericyte recruitment during vascular development. A brief account of the effects of Ndst1 deficiency in selective cell types in adult mice is also given.

Place, publisher, year, edition, pages
2010. Vol. 93, 35-58 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-138085DOI: 10.1016/S1877-1173(10)93003-2ISI: 000282063400003PubMedID: 20807640OAI: oai:DiVA.org:uu-138085DiVA: diva2:378824
Available from: 2010-12-16 Created: 2010-12-16 Last updated: 2011-06-28Bibliographically approved

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Ringvall, MariaKjellén, Lena

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