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Sudden infant death syndrome and Ljungan virus
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2009 (English)In: Forensic Science, Medicine, and Pathology, ISSN 1547-769X, Vol. 5, no 4, 274-279 p.Article in journal (Refereed) Published
Abstract [en]

Ljungan virus (LV) has recently been associated with perinatal death in its natural rodent reservoir and also with developmental disorders of reproduction in laboratory mice. A strong epidemiological association has been found between small rodent abundance in Sweden and the incidence of intrauterine fetal death (IUFD) in humans. LV antigen has been detected in half of the IUFD cases tested. The question was therefore raised whether sudden infant death syndrome (SIDS) might be associated with rodent abundance, and whether the virus is present in cases of SIDS. Variation in the incidence of SIDS using the Swedish cause-of-death database tracked the changes in the population fluctuations of native rodents. Formalin-fixed tissues from the brain, heart, and lung were investigated from cases of SIDS, SIDS with lymphocytic infiltration of the myocardium (myocarditis) and myocarditis cases using LV specific immunohistochemistry (IHC). Ljungan virus was detected in the brain, heart, and lung tissue from all three of the patient categories investigated using IHC. These studies suggest that LV may play a prominent role in infant death, and that IUFD and SIDS may have common etiological underpinnings.

Place, publisher, year, edition, pages
2009. Vol. 5, no 4, 274-279 p.
Keyword [en]
Forensic science, Sudden infant death, Sudden unexplained death in infants, Myocarditis, Ljungan virus, Zoonosis, Rodent virus, Immunohistochemistry
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-138120DOI: 10.1007/s12024-009-9086-8ISI: 000273261000005OAI: oai:DiVA.org:uu-138120DiVA: diva2:378888
Available from: 2010-12-16 Created: 2010-12-16 Last updated: 2010-12-16Bibliographically approved

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