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Release of folic acid in mesoporous NFM-1 silica.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
2010 (English)In: Journal of Nanoscience and Nanotechnology, ISSN 1533-4880, Vol. 10, no 11, 7398-401 p.Article in journal (Refereed) Published
Abstract [en]

Mesoporous NFM-1 silica with folic acid as template was prepared taking advantage of the supramolecular self-assembly of pterin groups and their abilities to form hexagonal liquid crystal phases. NFM-1 materials with the varied morphologies such as fiber, chiral twisting long-rod, gyroid, and amorphous particles were prepared by varying the amount of the co-structure directing agent, stirring speed and changing pH value of the synthesis. The release kinetics of NFM-1 samples with different morphologies were studied in phosphate buffer with pH = 7.4 in 37 degrees C under stirring. All the release kinetic curves are fitted by the power law and Higuchi equations. The fitting of the power law equation was separately done as for the released amount up to 60% or 100%. The materials show slow, long-term and sustained release of folic acid from mesoporous NFM-1 silica, which establishes a new foundation for the potential application in drug delivery and bioimaging.

Place, publisher, year, edition, pages
2010. Vol. 10, no 11, 7398-401 p.
National Category
Physical Sciences Engineering and Technology
URN: urn:nbn:se:uu:diva-138230DOI: 10.1166/jnn.2010.2823PubMedID: 21137944OAI: oai:DiVA.org:uu-138230DiVA: diva2:378953
Available from: 2010-12-16 Created: 2010-12-16 Last updated: 2014-12-11Bibliographically approved

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Garcia-Bennett, Alfonso E
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