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Variation in the catechol-O-methyltransferase Val(158)Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents
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2010 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 20, no 1, 20-24 p.Article in journal (Refereed) Published
Abstract [en]

Objective Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in populations with attention deficit/hyperactivity disorder (ADHD). This study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. In addition, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined. Method This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents. Results The Val allele of the Val(158)Met polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms. Conclusion The Val(158)Met polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population. Psychiatr Genet 20:20-24 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Place, publisher, year, edition, pages
2010. Vol. 20, no 1, 20-24 p.
Keyword [en]
antisocial behavior, attention deficit/hyperactivity disorder, catechol-O-methyltransferase, conduct disorder, genetics
National Category
Medical and Health Sciences Psychology
URN: urn:nbn:se:uu:diva-137847DOI: 10.1097/YPG.0b013e32833511e4ISI: 000273691000004OAI: oai:DiVA.org:uu-137847DiVA: diva2:379131
Available from: 2010-12-17 Created: 2010-12-16 Last updated: 2016-02-17Bibliographically approved

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Ruchkin, Vladislav V.
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Department of Neuroscience
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