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The Anionic Boron Cluster (B(12)H(11)SH)(2-) as a Means To Trigger Release of Liposome Contents.
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2007 (English)In: ChemMedChed, ISSN 1860-7179, Vol. 2, no 1, 51-53 p.Article in journal (Refereed) Published
Abstract [en]

Triggered release. Liposomes are novel carriers for pharmaceutical agents and can be triggered to release their contents by the addition of B12H11SH, a compound in clinical use. As systemic toxicity is decreased relative to the free drug, liposomal drugs can therefore be administered in higher concentrations before dose-limiting side effects are met. Thus, liposome-encapsulated drugs may be of great value in the therapy of diseases.

Place, publisher, year, edition, pages
2007. Vol. 2, no 1, 51-53 p.
Keyword [en]
boranes, calorimetry, cellular toxicity, leakage, liposomes
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-10148DOI: 10.1002/cmdc.200600227ISI: 000202946600004PubMedID: 17154431OAI: oai:DiVA.org:uu-10148DiVA: diva2:37916
Available from: 2007-02-28 Created: 2007-02-28 Last updated: 2011-04-19Bibliographically approved

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Karlsson, GöranEdwards, Katarina

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