uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Causal link between neonatal hydronephrosis and later development of hypertension
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi.
2010 (English)In: Clinical and experimental pharmacology & physiology, ISSN 0305-1870, E-ISSN 1440-1681, Vol. 37, no 2, E14-E23 p.Article in journal (Refereed) Published
Abstract [en]

1. Although congenital ureteral obstruction is a common disorder in infants, its pathophysiology remains poorly understood and its clinical management continues to be debated. During the past decade, the surgical management of non-symptomatic hydronephrosis in children has become more conservative, but the long-term physiological consequences of this new policy are unclear. 2. In experimental models with complete ureteral obstruction, tubular atrophy and interstitial inflammation occur rapidly. Although this type of obstruction is very rare in clinical practice, it is often referred to in clinical discussions. New studies, using a model with chronic partial ureteral obstruction, have demonstrated that hydronephrosis is associated with renal injuries and is causally related to hypertension. 3. The mechanisms underlying the development of hypertension in experimental hydronephrosis are complex and involve changes in both the renin-angiotensin system and renal sympathetic nerve activity. Furthermore, oxidative stress and nitric oxide deficiency in the diseased kidney, with consequent resetting of the tubuloglomerular feedback mechanism, appear to play a pivotal role in the development and maintenance of hypertension. 4. In view of the new knowledge regarding the long-term effects of partial ureteral obstruction, today's non-operative management of hydronephrosis should be reconsidered to prevent obstructive nephropathy and hypertension in later life.

Place, publisher, year, edition, pages
2010. Vol. 37, no 2, E14-E23 p.
Keyword [en]
nitric oxide, obstructive nephropathy, oxidative stress, renal denervation, renal sympathetic nerve activity, renin-angiotensin system, tubuloglomerular feedback, ureteral obstruction
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-137836DOI: 10.1111/j.1440-1681.2009.05267.xISI: 000273821300001OAI: oai:DiVA.org:uu-137836DiVA: diva2:379234
Available from: 2010-12-17 Created: 2010-12-16 Last updated: 2010-12-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Integrativ Fysiologi
In the same journal
Clinical and experimental pharmacology & physiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 197 hits
ReferencesLink to record
Permanent link

Direct link