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Synthesis and characterization of injectable composites of poly[D,L-lactide-co-(ε-caprolactone)] reinforced with β-TCP and CaCO3 for intervertebral disk augmentation.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry. (Polymer Chemistry)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
2010 (English)In: Journal of Biomedical Materials Research, Part B: Applied Biomaterials, ISSN 15524973, Vol. 95B, no 1, 75-83 p.Article in journal (Refereed) Published
Abstract [en]

Degeneration of the intervertebral disk constitutes one of the major causes of low back pain in adults aged 2050 years old. In this study, injectable, in situ setting, degradable composites aimed for intervertebral disk replacement were prepared. beta-TCP and calcium carbonate particles were mixed into acrylic-terminated oligo[D,L-lactide-co-(epsilon-caprolactone)], which were crosslinked at room temperature. The structure of the oligomers was confirmed by H-1-NMR spectroscopy. The composites were examined via SEM, and the mechanical properties of the crosslinked networks were determined. The porous beta-TCP particles showed good mechanical anchorage to the matrix due to polymer penetration into the pores. In vitro degradation tests showed that the composites containing beta-TCP slowly degraded, whereas the composites containing CaCO3 exhibited apatite formation capacity. It was concluded that the surface area, morphology, and solubility of the fillers might be used to control the degradation properties. The incorporation of fillers also increased both the elastic modulus and the maximum compression strength of the composites, properties that were similar to those of the physiological disk. These materials have potential for long-term intervertebral disk replacement and regenerative scaffolds because of their low degradation rates, bioactivity, and mechanical properties.

Place, publisher, year, edition, pages
Wiley Periodicals, Inc. , 2010. Vol. 95B, no 1, 75-83 p.
Keyword [en]
intervertebral disk, degradable polymer(s), calcium phosphate(s), calcium carbonate(s), injectable composite(s)
National Category
Polymer Chemistry Engineering and Technology
Research subject
Engineering Science with specialization in Materials Science; Chemistry with specialization in Polymer Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-138503DOI: 10.1002/jbm.b.31685ISI: 000281655900010OAI: oai:DiVA.org:uu-138503DiVA: diva2:379330
Available from: 2010-12-17 Created: 2010-12-17 Last updated: 2014-12-10Bibliographically approved

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Publisher's full texthttp://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31685/abstract?systemMessage=Due+to+essential+maintenance%2C+access+to+Wiley+Online+Library+will+be+disrupted+on+Sunday%2C+19th+Dec+between+10%3A00-12%3A00+GMT

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López, AlejandroPersson, CeciliaHilborn, JönsEngqvist, Håkan

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