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The eosinophil and airway remodelling in asthma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2010 (English)In: The Clinical Respiratory Journal, ISSN 1752-6981, Vol. 4, no S1, 15-19 p.Article, review/survey (Refereed) Published
Abstract [en]

Objectives: Eosinophils are common findings cells in allergic asthma as is sub-base membrane thickening of the airways. The objective of this review was to summarise some recent findings linking the activities of eosinophils to airways remodelling. Data Source and Study Selection: The study used a review of current literature with emphasis on our own recent findings. Results: Eosinophils are found at increased numbers in asthma and more so in allergic as compared with non-allergic asthma. A link has been found in several clinical studies on allergic asthmatics, but not in studies on non-allergic asthma, between the presence of eosinophils and signs of airways remodelling. The eosinophil contains and secretes several pro-fibrogenic molecules such as eosinophil cationic protein (ECP) and transforming growth factor beta (TGF-beta). Genetic studies on subjects developing liver fibrosis as a consequence of Schistosoma mansoni infection show close relationships to ECP genotypes. Conclusion: Several clinical and experimental studies indicate that eosinophils contribute to airways remodelling not only through their secretion of cationic proteins such as ECP and cytokines such as TGF-beta 1, but also through interactions with mast cells and epithelial cells.

Place, publisher, year, edition, pages
2010. Vol. 4, no S1, 15-19 p.
Keyword [en]
airways, basement membrane, ECP, eosinophil, fibrosis, laminin, TGF beta
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-138375DOI: 10.1111/j.1752-699X.2010.00192.xISI: 000276695800003OAI: oai:DiVA.org:uu-138375DiVA: diva2:380166
Available from: 2010-12-20 Created: 2010-12-17 Last updated: 2010-12-20Bibliographically approved

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