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Sensitive protein detection via triple-binder proximity ligation assays
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2007 (English)In: Nature Methods, ISSN 1548-7091, E-ISSN 1548-7105, Vol. 4, no 2, 135-137 p.Article in journal (Refereed) Published
Abstract [en]

The detection of weakly expressed proteins and protein complexes in biological samples represents a fundamental challenge. We have developed a new proximity-ligation strategy named 3PLA that uses three recognition events for the highly specific and sensitive detection of as little as a hundred molecules of the vascular endothelial growth factor (VEGF), the biomarkers troponin I, and prostate-specific antigen (PSA) alone or in complex with an inhibitor--demonstrating the versatility of 3PLA.

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2007. Vol. 4, no 2, 135-137 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-10282DOI: 10.1038/nmeth974ISI: 000243998100014PubMedID: 17179939OAI: oai:DiVA.org:uu-10282DiVA: diva2:38050
Available from: 2007-03-12 Created: 2007-03-12 Last updated: 2011-02-14Bibliographically approved

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Schallmeiner, EdithEricsson, OlleSpångberg, LenaLandegren, Ulf

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