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Androgen levels, insulin sensitivity, and early insulin response in women with polycystic ovary syndrome: a long-term follow-up study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Reproduktiv hälsa/Sundström Poromaa)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Reproduktiv hälsa/Sundström Poromaa)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
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2011 (English)In: Fertility and Sterility, ISSN 0015-0282, E-ISSN 1556-5653, Vol. 95, no 3, 1146-1148 p.Article in journal (Refereed) Published
Abstract [en]

Thirty-four women with polycystic ovary syndrome who previously had participated in studies with intravenous glucose tolerance test and hyperinsulinemic, euglycemic clamp between 1987 and 1995 underwent anthropometric, endocrine (T and sex-hormone binding globulin serum concentration), and metabolic (intravenous glucose tolerance test, hyperinsulinemic, euglycemic clamp, and androgens) measurements. Free androgen levels and β-cell function decreased over time in women with polycystic ovary syndrome, but insulin sensitivity remained unaltered.

Place, publisher, year, edition, pages
2011. Vol. 95, no 3, 1146-1148 p.
Keyword [en]
Polycystic ovary syndrome, long-term follow-up, insulin sensitivity, intravenous glucose tolerance test, hyperinsulinemic, euglycemic clamp, testosterone
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-139204DOI: 10.1016/j.fertnstert.2010.09.050ISI: 000287480300073PubMedID: 21036351OAI: oai:DiVA.org:uu-139204DiVA: diva2:380761
Available from: 2010-12-22 Created: 2010-12-22 Last updated: 2017-12-11Bibliographically approved
In thesis
1. Reproductive and Metabolic Consequences of the Polycystic Ovarian Syndrome
Open this publication in new window or tab >>Reproductive and Metabolic Consequences of the Polycystic Ovarian Syndrome
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Polycystic ovary syndrome (PCOS) is a complex clinical condition characterized by hyperandrogenism and chronic oligo/anovulation. Infrequent ovulation and metabolic alterations in women with PCOS are associated with subfertility and probably increased miscarriage rates compared with normal fertile women. The overall risk of developing type 2 diabetes and impaired glucose tolerance (IGT) is three- to sevenfold higher in PCOS women, and the onset of glucose intolerance seems to occur at an earlier age than in healthy controls. Women with PCOS also have several risk factors for cardiovascular disease, although it is unclear whether they actually experience more cardiovascular events than other women. Very few studies assessing the long-term reproductive and metabolic consequences in older women with previously confirmed PCOS have been conducted. In this long-term follow-up of women with PCOS, 84 women with a diagnosis of PCOS between 1987 and 1995 and age at the follow-up > 35 years and an age-matched population-based group of control women participated. Data on reproductive outcome, ovarian reserve, endothelial function, insulin sensitivity and beta-cell function were collected. According to our results most women with PCOS had given birth and the rate of spontaneous pregnancies was relatively high. The rate of miscarriages was not increased in PCOS patients and the ultrasound findings together with increased levels of anti-müllerian hormone suggested that their ovarian reserve is superior to women of similar age. PCOS women displayed signs of endothelial dysfunction, but this was largely due to the increased prevalence of independent risk factors for cardiovascular disease such as increased BMI, triglycerides and blood pressures. IGT and type 2 diabetes occurred more often in PCOS women. Free androgen levels and beta-cell function decreased over time whereas insulin sensitivity remained unchanged. Obesity at young age and progressive weight-gain rendered them more prone to be insulin resistant at the follow-up. Beta-cell function was increased in PCOS women in comparison with control subjects but declined over time. Independent of PCOS phenotype at the index assessment and persistence of PCOS symptoms at the follow-up investigation, premenopausal women with PCOS had lower insulin sensitivity and increased beta cell function in comparison with control subjects. Conclusion: The long-term reproductive outcomes of PCOS are similar compared to women with normal ovaries. Although symptoms and androgen levels are normalized over time, women with PCOS continue to display reduced insulin sensitivity and increased beta-cell function and they also have an increased risk of IGT and type 2 diabetes.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2010. 73 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 570
Keyword
polycystic ovarian syndrome, long-term follow-up, ovarian reserve, anti-Müllerian hormone, insulin sensitivity, early insuline response, impaired glucose tolerance, diabetes, endothelial function, endothelial-dependent vasodilation
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
Identifiers
urn:nbn:se:uu:diva-123248 (URN)978-91-554-7826-1 (ISBN)
Public defence
2010-06-14, Rosénsalen, Uppsala University Hospital, Entrance 95/96, Uppsala, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2010-05-24 Created: 2010-04-26 Last updated: 2012-08-24

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Hudecova, MiriamMoby, LenaOlovsson, MattsStridsberg, MatsLarsson, AndersBerglund, LarsBerne, ChristianSundström Poromaa, Inger

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Hudecova, MiriamMoby, LenaOlovsson, MattsStridsberg, MatsLarsson, AndersBerglund, LarsBerne, ChristianSundström Poromaa, Inger
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Obstetrics and GynaecologyDepartment of Women's and Children's HealthBiochemical endocrinologyBiochemial structure and functionUCR-Uppsala Clinical Research CenterEndocrinology, Diabetes and Metabolism
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