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A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
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2010 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 42, no 12, 1126-1130 p.Article in journal, Letter (Refereed) Published
Abstract [en]

To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10−8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10−13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10−8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10−50). These data provide new insight into the pathogenesis of cHL.

Place, publisher, year, edition, pages
2010. Vol. 42, no 12, 1126-1130 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-139261DOI: 10.1038/ng.696ISI: 000284578800017OAI: oai:DiVA.org:uu-139261DiVA: diva2:380936
Available from: 2010-12-22 Created: 2010-12-22 Last updated: 2017-12-11Bibliographically approved

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Glimelius, BengtMolin, Daniel

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