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Arsenic Exposure in Pregnancy Increases the Risk of Lower Respiratory Tract Infection and Diarrhea During Infancy in Bangladesh
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Internationell barnhälsa och nutrition/Persson)
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Internationell kvinno- & mödrahälsovård/Essén)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Internationell barnhälsa och nutrition/Persson)
2011 (English)In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 119, no 5, 719-724 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Previous studies have reported associations between prenatal arsenic exposure and increased risk of infant mortality. An increase in infectious diseases has been proposed as the underlying cause of these associations, but there is no epidemiological research to support the hypothesis. We evaluated the association between arsenic exposure in pregnancy and morbidity during infancy. METHODS: This prospective population-based cohort study included 1,552 live-born infants of women enrolled during 2002 -2004 in Matlab, Bangladesh. Arsenic exposure was assessed by the concentrations of metabolites of inorganic arsenic in maternal urine samples collected at gestational week 8 and 30. Information on symptoms of lower respiratory tract infection (LRTI) and diarrhea in infants was collected by 7-days recalls at monthly home visits. RESULTS: In total 115,850 person-days of observation were contributed by the infants over a 12 months follow-up period. The estimated risk of LRTI and severe LRTI increased by 69% (adjusted relative risk (RR) 1.69, 95% confidence intervals (CI): 1.36 - 2.09) and 54% (RR 1.54, 95% CI: 1.21 - 1.97), respectively, for infants of mothers with urinary arsenic concentrations in the highest quintile (262 - 977 µg/L, average of arsenic concentrations measured in early and late gestation) relative to those with exposure in the lowest quintile (<39 µg/L). The corresponding figure for diarrhea was 20% (RR 1.20, 95% CI: 1.01 - 1.43). CONCLUSIONS: Arsenic exposure during pregnancy was associated with increased morbidity in infectious diseases during infancy. Taken together with the previous evidence of adverse effects on health, the findings strongly emphasize the need to reduce arsenic exposure via drinking water.

Place, publisher, year, edition, pages
2011. Vol. 119, no 5, 719-724 p.
Keyword [en]
arsenic, Bangladesh, diarrhea, infants, pregnancy, respiratory tract infection
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-139330DOI: 10.1289/ehp.1002265ISI: 000290089800041PubMedID: 21147604OAI: oai:DiVA.org:uu-139330DiVA: diva2:380997
Available from: 2010-12-22 Created: 2010-12-22 Last updated: 2017-12-11Bibliographically approved

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Rahman, AnisurEkström, Eva-CharlottePersson, Lars-Åke

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