A New Era in the Diagnosis and Treatment of Breast Cancer
2010 (English)In: The Breast Journal, ISSN 1075-122X, E-ISSN 1524-4741, Vol. 16, S2-S4 p.Article in journal (Refereed) Published
Randomized controlled mammography screening trials and the evaluation of service screening have unequivocally proven that regular mammography screening significantly reduces mortality from breast cancer. This evidence contradicts the theory of Fisher, claiming that breast cancer is a systemic disease from its inception and undermines the justification for systemic therapy in most screen-detected cancers, because they are still localized to the breast and can be cured by local treatment alone. When high quality mammographic screening is offered at regular intervals to 40- to 74-year-old women, over 50% of the invasive cancers will be detected in the size range of 1-14 mm, fewer than 20% will be axillary node positive, and only about 20% will be poorly differentiated. This predominance of early-stage disease has created a revolutionary new era for those involved in the diagnosis and treatment of patients with breast cancer.
Place, publisher, year, edition, pages
2010. Vol. 16, S2-S4 p.
breast cancer, early detection, mammography screening, multifocal breast cancer, randomized controlled trial
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-139354DOI: 10.1111/j.1524-4741.2010.00992.xISI: 000283986900002OAI: oai:DiVA.org:uu-139354DiVA: diva2:381050