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Interaction between amphiphilic peptides and phospholipid membranes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.ORCID iD: 0000-0001-9070-6944
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2010 (English)In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, E-ISSN 1879-0399, Vol. 15, no 6, 467-478 p.Article, review/survey (Refereed) Published
Abstract [en]

This brief review aims at providing some illustrative examples on the interaction between amphiphilic peptides and phospholipid membranes an area of significant current interest Focusing on antimicrobial peptides factors affecting peptide-membrane interactions are addressed including effects of peptide length charge hydrophobicity secondary structure and topology Effects of membrane composition are also illustrated including effects of membrane charge nature of the polar headgroup and presence of cholesterol and other sterols Throughout novel insights on the importance of peptide adsorption density on membrane stability are emphasized as is the correlation between peptide adsorption peptide induced leakage in model liposome systems peptide-induced lysis of bacteria and bacteria killing.

Place, publisher, year, edition, pages
2010. Vol. 15, no 6, 467-478 p.
Keyword [en]
AMP, Antimicrobial peptide, Bacteria, Liposome, Membrane
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-139412DOI: 10.1016/j.cocis.2010.05.006ISI: 000284520000009OAI: oai:DiVA.org:uu-139412DiVA: diva2:381084
Available from: 2010-12-23 Created: 2010-12-23 Last updated: 2017-12-11Bibliographically approved

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Strömstedt, Adam A.Malmsten, Martin
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