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Biomacromolecules in microgels - Opportunities and challenges for drug delivery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2010 (English)In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, E-ISSN 1879-0399, Vol. 15, no 6, 435-444 p.Article, review/survey (Refereed) Published
Abstract [en]

This brief review alms at providing some illustrative examples on the interaction between microgels and biological macromolecules with special focus on peptides and proteins as well as current applications of such systems in drug delivery In doing so novel insights on factors affecting peptide/protein incorporation to distribution within and release from sparsely cross linked microgels are addressed including effects of network charge and cross linking density as well as peptide/protein length/size charge (distribution) and hydrophobicity Effects of ambient conditions are also illustrated with special focus on pH and ionic strength Notably factors precluding the application of microgel systems in biomacromolecular drug delivery e g shell formation and incomplete drug release are discussed together with challenges and opportunities of these effects in the application of biomacromolecule/microgel systems in drug delivery.

Place, publisher, year, edition, pages
2010. Vol. 15, no 6, 435-444 p.
Keyword [en]
Biomacromolecules, Drug delivery, Microgel, Microcapsule, Peptide, Protein
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-139411DOI: 10.1016/j.cocis.2010.05.016ISI: 000284520000006OAI: oai:DiVA.org:uu-139411DiVA: diva2:381085
Available from: 2010-12-23 Created: 2010-12-23 Last updated: 2017-12-11Bibliographically approved

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