Ventilation practices in the neonatal intensive care unit: a cross-sectional study
2010 (English)In: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 157, no 5, 767-U101 p.Article in journal (Refereed) Published
Objective To assess current ventilation practices in newborn infants.
Study design We conducted a 2-point cross-sectional study in 173 European neonatal intensive care units, including 535 infants (mean gestational age 28 weeks and birth weight 1024 g). Patient characteristics, ventilator settings, and measurements were collected bedside from endotracheally ventilated infants.
Results A total of 457 (85%) patients were conventionally ventilated. Time cycled pressure-limited ventilation was used in 59% of these patients, most often combined with synchronized intermittent mandatory ventilation (51%). Newer conventional ventilation modes like volume targeted and pressure support ventilation were used in, respectively, 9% and 7% of the patients. The mean tidal volume, measured in 84% of the conventionally ventilated patients, was 5.7 +/- 2.3 ml/kg. The mean positive end-expiratory pressure was 4.5 +/- 1.1 cmH(2)O and rarely exceeded 7 cmH(2)O.
Conclusions Time cycled pressure-limited ventilation is the most commonly used mode in neonatal ventilation. Tidal volumes are usually targeted between 4 to 7 mL/kg and positive end-expiratory pressure between 4 to 6 cmH(2)O. Newer ventilation modes are only used in a minority of patients. (J Pediatr 2010; 157:767-71).
Place, publisher, year, edition, pages
2010. Vol. 157, no 5, 767-U101 p.
IdentifiersURN: urn:nbn:se:uu:diva-139515DOI: 10.1016/j.jpeds.2010.05.043ISI: 000283045900019PubMedID: 20619854OAI: oai:DiVA.org:uu-139515DiVA: diva2:381493
Co-author: Richard Sindelar, Uppsala universitet, Institutionen för kvinnors och barns hälsa, forskargrupp Perinatal, neonatal och barnkardiologisk forskning/Jonzon, ingår i Neovent Study Group.
A list of Neovent Study Group members is available in the Appendix.2010-12-272010-12-272016-10-03Bibliographically approved