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TGF-beta signaling from a three-dimensional perspective: insight into selection of partners
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
2002 (English)In: Trends in Cell Biolology, ISSN 0962-8924, E-ISSN 1879-3088, Vol. 12, no 7, 304-307 p.Article, review/survey (Refereed) Published
Abstract [en]

Members of the transforming growth factor beta (TGF-beta) family, which include TGF-beta s, activins and bone morphogenetic proteins (BMPs), are potent regulators of cell proliferation, differentiation, migration and apoptosis. They act through binding to and activating serine/threonine kinase receptors on the cell surface and triggering intracellular signaling pathways in which Smad proteins have essential roles. Here, we discuss recent structure-based studies of TGF-beta s and BMPs, their receptors, and of Smad proteins, which have unravelled insights into ligand specificity, receptor and Smad activation, as well as new features of Smads as phosphoserine-binding entities.

Place, publisher, year, edition, pages
2002. Vol. 12, no 7, 304-307 p.
Keyword [en]
Animals, Bone Morphogenetic Proteins/chemistry/physiology, Crystallography; X-Ray, DNA-Binding Proteins/chemistry/physiology, Humans, Models; Molecular, Protein Conformation, Signal Transduction, Smad Proteins, Trans-Activators/chemistry/physiology, Transforming Growth Factor beta/*chemistry/physiology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-10419DOI: 10.1016/S0962-8924(02)02300-0PubMedID: 12185845OAI: oai:DiVA.org:uu-10419DiVA: diva2:38187
Available from: 2007-03-22 Created: 2007-03-22 Last updated: 2017-12-11Bibliographically approved

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Souchelnytskyi, SerhiyMoustakas, AristidisHeldin, Carl-Henrik

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