TGF-beta signaling from a three-dimensional perspective: insight into selection of partners
2002 (English)In: Trends in Cell Biolology, ISSN 0962-8924, E-ISSN 1879-3088, Vol. 12, no 7, 304-307 p.Article, review/survey (Refereed) Published
Members of the transforming growth factor beta (TGF-beta) family, which include TGF-beta s, activins and bone morphogenetic proteins (BMPs), are potent regulators of cell proliferation, differentiation, migration and apoptosis. They act through binding to and activating serine/threonine kinase receptors on the cell surface and triggering intracellular signaling pathways in which Smad proteins have essential roles. Here, we discuss recent structure-based studies of TGF-beta s and BMPs, their receptors, and of Smad proteins, which have unravelled insights into ligand specificity, receptor and Smad activation, as well as new features of Smads as phosphoserine-binding entities.
Place, publisher, year, edition, pages
2002. Vol. 12, no 7, 304-307 p.
Animals, Bone Morphogenetic Proteins/chemistry/physiology, Crystallography; X-Ray, DNA-Binding Proteins/chemistry/physiology, Humans, Models; Molecular, Protein Conformation, Signal Transduction, Smad Proteins, Trans-Activators/chemistry/physiology, Transforming Growth Factor beta/*chemistry/physiology
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-10419DOI: 10.1016/S0962-8924(02)02300-0PubMedID: 12185845OAI: oai:DiVA.org:uu-10419DiVA: diva2:38187