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CIN85/CMS family of adaptor molecules.
Ludwiginstitutet för Cancerforskning.
2002 (English)In: FEBS Lett, ISSN 0014-5793, Vol. 529, no 1, 110-5 p.Article, review/survey (Other (popular scientific, debate etc.)) Published
Abstract [en]

CIN85 and CMS belong to a family of ubiquitously expressed adaptor molecules containing three SH3 domains, a proline-rich region and a coiled-coil domain. By binding to numerous proteins they assemble multimeric complexes implicated in cell-specific signals controlling T-cell activation, kidney glomeruli function or apoptosis in neuronal cells. CIN85/CMS also associate with accessory endocytic proteins, components of the actin cytoskeleton as well as other adaptor proteins involved in receptor tyrosine kinase (RTK) signaling. These interactions enable CIN85/CMS to function within a network of signaling pathways that co-ordinate critical steps involved in downregulation and degradation of RTKs.

Place, publisher, year, edition, pages
2002. Vol. 529, no 1, 110-5 p.
Keyword [en]
Adaptor Proteins; Signal Transducing, Animals, Carrier Proteins/*chemistry/*metabolism, Cytoskeletal Proteins, Endocytosis, Humans, Kidney/physiology, Proteins/chemistry/immunology/metabolism, Receptor Protein-Tyrosine Kinases/metabolism
URN: urn:nbn:se:uu:diva-10467PubMedID: 12354621OAI: oai:DiVA.org:uu-10467DiVA: diva2:38235
Available from: 2007-03-26 Created: 2007-03-26 Last updated: 2011-01-13

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