uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
A two-terminal silicon nanoribbon field-effect pH sensor
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
Show others and affiliations
2010 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 97, no 26, 264102- p.Article in journal (Refereed) Published
Abstract [en]

This paper reports on a two-terminal silicon nanoribbon (SiNR) field-effect pH sensor operated in electrolyte. Observed experimentally and confirmed by modeling, the sensor is activated by self-gating with a gate bias set by the potential difference of the two terminals. The effect of this gate bias on the SiNR conductance is modulated by the potential drop over the electrical double layer (EDL) established on the SiNR surface, similarly to the threshold voltage modulation by EDL in a three-terminal SiNR field-effect transistor with an independent gate electrode. The potential drop over EDL is determined by the pH value of the electrolyte.

Place, publisher, year, edition, pages
2010. Vol. 97, no 26, 264102- p.
National Category
Engineering and Technology
URN: urn:nbn:se:uu:diva-139888DOI: 10.1063/1.3532964ISI: 000285768100095OAI: oai:DiVA.org:uu-139888DiVA: diva2:382379
Available from: 2010-12-30 Created: 2010-12-30 Last updated: 2016-04-18Bibliographically approved
In thesis
1. Electronic Sensors Based on Nanostructured Field-Effect Devices
Open this publication in new window or tab >>Electronic Sensors Based on Nanostructured Field-Effect Devices
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Point-of-care (POC) diagnostics presents a giant market opportunity with profound societal impact. In particular, specific detection of DNA and protein markers can be essential for early diagnosis of e.g. cancer, cardiovascular disease, infections or allergies. Today, identification of these markers often requires extensive laboratory work and hence is expensive and time consuming. Current methods for recognition and detection of specific biomolecules are mostly optics based and thus impose severe limitations as to convenience, specificity, sensitivity, parallel processing and cost reduction.

Electronic sensors based on silicon nanowire field-effect transistors have been reported to be able to detect biomolecules with concentrations down to femtomolar (fM) level with high specificity. Although the reported capability needs further confirmation, the CMOS-compatible fabrication process of such sensors allows for low cost production and high density integration, which are favorable for POC applications. This thesis mainly focuses on the development of a multiplex detection platform based on silicon nanowire field-effect sensors integrated with a microfluidic system for liquid sample delivery. Extensive work was dedicated to developing a top-down fabrication process of the sensors as well as an effective passivation scheme. The operation mechanism and coupling efficiencies of different gate configurations were studied experimentally with the assistance of numerical simulation and equivalent circuits. Using pH sensing as a model system, large effort was devoted to identifying sources for false responses resulting from the instability of the inert-metal gate electrode. In addition, the drift mechanism of the sensor operating in electrolyte was addressed and a calibration model was proposed. Furthermore, protein detection experiments were performed using small-sized Affibody molecules as receptors on the gate insulator to tackle the Debye screening issue. Preliminary results showed that the directionality of the current changes in the sensors was in good agreement with the charge polarities of the proteins. Finally, a graphene-based capacitor was examined as an alternative to the nanowire device for field-effect ion sensing. Our initial attempts showed some attractive features of the capacitor sensor.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2013. 71 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1018
biosensor, field-effect transistor, nanowire, ISFET
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering Nano Technology
Research subject
urn:nbn:se:uu:diva-194015 (URN)978-91-554-8596-2 (ISBN)
Public defence
2013-03-27, Häggsalen, Ångström Laboratory, Lägerhyddsvägen 1, Uppsala, 10:00 (English)
Available from: 2013-03-05 Created: 2013-02-07 Last updated: 2013-04-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Zhan, Shi-Li
By organisation
Solid State Electronics
In the same journal
Applied Physics Letters
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 414 hits
ReferencesLink to record
Permanent link

Direct link