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Transforming growth factor-beta signaling and its role in cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
2002 (English)In: Experimental Oncology, ISSN 0204-3564, Vol. 24, no 1, 3-12 p.Article, review/survey (Other (popular science, discussion, etc.)) Published
Abstract [en]

Transforming growth factor-b (TGFb) is a polypeptide growth factor, which regulates cell proliferation, differentiation, migration and apoptosis. During the last decade an exploration of mechanisms of TGFb receptor activation and discovery of Smads has stimulated significant progress in decoding of intracellular signaling of TGFb. These advancements request a re-evaluation of role of TGFb in human diseases. This review discusses recent achievements in understanding of the mechanisms governing TGFb signaling, with emphasis on overview of the role of TGFb in tumorigenesis.

Place, publisher, year, edition, pages
2002. Vol. 24, no 1, 3-12 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-10472ISI: 000175040000001OAI: oai:DiVA.org:uu-10472DiVA: diva2:38240
Available from: 2007-03-26 Created: 2007-03-26 Last updated: 2013-11-12Bibliographically approved

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Souchelnytskyi, Serhiy
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