Does socioeconomic status influence the prospect of cure from colon cancer - A population-based study in Sweden 1965-2000
2010 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 46, no 16, 2965-2972 p.Article in journal (Refereed) Published
Aim of study Differences in the survival of colon cancer patients by socioeconomic status have been demonstrated in several populations but the underlying reasons for the differences are not well understood By simultaneously estimating the proportion of patients cured from colon cancer and the survival times of the uncured we hope to increase under standing of how socioeconomic status affects survival following a diagnosis of colon cancer Methods We conducted a population based cohort study of 58 873 patients diagnosed with colon cancer in Sweden 1965-2000 Socioeconomic status was classified based on occupation We fitted mixture cure models and Poisson regression models adjusted for age sex and calendar period Results We observed higher excess mortality lower proportion cured and shorter survival times among the uncured in patients from lower socioeconomic groups compared to the highest socioeconomic group There was no evidence that the gap between the socioeconomic groups reduced over time Farmers had the lowest odds of cure (odds ratio (OR) 0 85 95% confidence interval (Cl) 0 75-0 95) compared to higher non manual workers followed by self employed (0 91, 0 81-1 03) manual workers (0 93, 0 85-1 03) and lower non manual workers (0 91 0 89-1 08) Conclusion Patients from lower socioeconomic groups in Sweden experience worse survival following a diagnosis of colon cancer Differences exist in both the cure proportion and the survival time of the uncured suggesting that socioeconomic differences cannot be attributed solely to lead time bias Although this study has furthered our under standing of socioeconomic differences in survival more detailed studies are required in order to identify and subsequently remove the underlying reasons for the differences.
Place, publisher, year, edition, pages
2010. Vol. 46, no 16, 2965-2972 p.
Colon cancer, Socioeconomic status, Survival, Statistical cure, Excess mortality
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-140044DOI: 10.1016/j.ejca.2010.05.028ISI: 000284968400020PubMedID: 20580545OAI: oai:DiVA.org:uu-140044DiVA: diva2:382804