uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Randomized phase II study of sequential docetaxel and irinotecan with 5-fluorouracil/folinic acid (leucovorin) in patients with advanced gastric cancer: the GATAC trial
Show others and affiliations
2010 (English)In: Gastric Cancer, ISSN 1436-3291, E-ISSN 1436-3305, Vol. 13, no 3, 155-161 p.Article in journal (Refereed) Published
Abstract [en]

Background. The optimal chemotherapy in patients with advanced gastric carcinoma (GC) is yet to be determined. We compared sequential administration of docetaxel and irinotecan, both in combination with infused 5-fluorouracil/leucovorin (5-Fu/Lv), and randomly assigned patients to start with either of the two. Methods. Patients with previously untreated locally advanced or metastatic GC and with measurable lesions (response evaluation criteria in solid tumors; RECIST) were randomly assigned to start with docetaxel 45 m (arm T) or irinotecan 180 mg/m(2) (arm C) with bolus/44-h infusion of 5-Fu/Lv (day 1 every 2 weeks). After four courses, there was a pre-scheduled crossover to the alternative regimen for four additional courses. Results. Eighty-one patients were randomized and 78 started treatment. Complete and partial responses were seen in 31 (40%) patients after 8 weeks and in 32 (41%) after 16 weeks, with similar results in both study arms. The median overall survival (OS) was 11.5 and 10.6 months in arms T and C, respectively (P = 0.3). The two schedules were feasible and did not differ in the overall rate of severe adverse events (SAEs). Conclusion. This is the first randomized comparison of two of the newer cytostatic drugs in GC therapy. No differences favoring either arm T or arm C were found with respect to response rate, OS, or toxicity. The median OS of 11 months indicates that sequential administration of the two combinations is effective and is similar to triple combinations. Thus, comparable efficacy to platinum combinations appears to be obtained with newer, less toxic regimens when given sequentially.

Place, publisher, year, edition, pages
2010. Vol. 13, no 3, 155-161 p.
Keyword [en]
Gastric cancer, Palliative treatment, Chemotherapy, Sequential treatment, Docetaxel, Irinotecan
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-140042DOI: 10.1007/s10120-010-0553-4ISI: 000284961300003PubMedID: 20820984OAI: oai:DiVA.org:uu-140042DiVA: diva2:382810
Available from: 2011-01-03 Created: 2011-01-03 Last updated: 2011-01-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Oncology, Radiology and Clinical Immunology
In the same journal
Gastric Cancer
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 142 hits
ReferencesLink to record
Permanent link

Direct link