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Bioactive eicosanoids: Role of prostaglandin F-2 alpha and F-2-isoprostanes in inflammation and oxidative stress related pathology
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
2010 (English)In: Molecules and Cells, ISSN 1016-8478, E-ISSN 0219-1032, Vol. 30, no 5, 383-391 p.Article, review/survey (Refereed) Published
Abstract [en]

Oxidative stress and inflammation are supposed to be the key players of several acute and chronic diseases, and also for progressive aging process. Eicosanoids, especially prostaglandin F-2 alpha (PGF(2 alpha)) and F-2-isoprostanes are endogenous compounds that are involved both in physiology and the above mentioned pathologies. These compounds are biosynthesized mainly from esterified arachidonic acid through both enzymatic and non-enzymatic free radical-catalysed reactions in vivo, respectively. They have shown to possess potent biological activities in addition to their application as biomarkers of oxidative stress and inflammation. Recent advancement of methodologies has made it possible to quantify these compounds more reliably and apply them in various in vivo studies successfully. Today, experimental and clinical studies have revealed that both PGF(2 alpha) and F-2-isoprostanes are involved in severe acute or chronic inflammatory conditions such as rheumatic diseases, asthma, risk factors of atherosclerosis, diabetes, ischemia-reperfusion, septic shock and many others. These evidences promote that assessment of bioactive PGF(2 alpha) and F-2-isoprostanes simultaneously in body fluids offers unique non-invasive analytical opportunity to study the function of these eicosanoids in physiology, oxidative stress-related and inflammatory diseases, and also in the determination of potency of various radical scavengers, anti-inflammatory compounds, drugs, antioxidants and diet.

Place, publisher, year, edition, pages
2010. Vol. 30, no 5, 383-391 p.
Keyword [en]
eicosanoids, inflammation, isoprostanes, oxidative stress, prostaglandins
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-140031DOI: 10.1007/s10059-010-0157-1ISI: 000284697600001PubMedID: 21113821OAI: oai:DiVA.org:uu-140031DiVA: diva2:382852
Available from: 2011-01-03 Created: 2011-01-03 Last updated: 2011-01-03Bibliographically approved

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