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Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
2010 (English)In: Nutrition reviews, ISSN 0029-6643, E-ISSN 1753-4887, Vol. 68, no 12, S128-S134 p.Article, review/survey (Refereed) Published
Abstract [en]

The identification of disease-causing mutations in Alzheimer's disease has contributed greatly to the understanding of the pathogenesis of this disease. The amyloid-beta (A beta) peptide has come into focus and is believed to be central to the pathogenesis of Alzheimer's disease. With only symptomatic treatment available, efforts to develop new therapeutics aimed at lowering the amount of A beta peptides in the affected brain have intensified. In particular, immunotherapy against A beta peptides has attracted considerable interest, as it offers the possibility to generate highly specific molecules targeting highly specific moieties. Due to intense research efforts and massive investments at universities and in the pharmaceutical industry, the outlook for patients and their relatives has never been brighter.

Place, publisher, year, edition, pages
2010. Vol. 68, no 12, S128-S134 p.
Keyword [en]
Alzheimer's disease, amyloid-beta protein, immunotherapy, protofibrils, transgenic mice
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-140029DOI: 10.1111/j.1753-4887.2010.00347.xISI: 000284587300010PubMedID: 21091946OAI: oai:DiVA.org:uu-140029DiVA: diva2:382857
Available from: 2011-01-03 Created: 2011-01-03 Last updated: 2017-12-11Bibliographically approved

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