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Luteal phase progesterone increases live birth rate after frozen embryo transfer
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm.
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm.
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
2011 (English)In: Fertility and Sterility, ISSN 0015-0282, E-ISSN 1556-5653, Vol. 95, no 2, 534-537 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To see if progesterone support has a beneficial effect on live birth rate after frozen embryo transfer in natural cycles. DESIGN: Prospective randomized controlled trial. SETTING: University-based hospital. SUBJECT(S): Four hundred thirty-five women undergoing embryo transfer in natural cycles. INTERVENTION(S): The women received either vaginal progesterone, 400 mg twice a day from the day of embryo transfer in natural cycles, or no progesterone support. MAIN OUTCOME MEASURE(S): Live birth rate, biochemical pregnancy rate, pregnancy rate, and spontaneous abortion rate. RESULT(S): Live birth rate were significantly greater in women receiving vaginal progesterone as luteal phase support after frozen-thawed embryo transfer in natural cycles compared with those who did not take progesterone. There were no differences in biochemical pregnancy rate, pregnancy rate, or spontaneous abortion rate. CONCLUSION(S): Progesterone supplementation improves live birth rate after embryo transfer in natural cycles.

Place, publisher, year, edition, pages
2011. Vol. 95, no 2, 534-537 p.
Keyword [en]
frozen embryo transfer, live birth rate, natural menstrual cycle, pregnancy rate, Progesterone
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-140104DOI: 10.1016/j.fertnstert.2010.05.019ISI: 000286419000023PubMedID: 20579989OAI: oai:DiVA.org:uu-140104DiVA: diva2:382936
Available from: 2011-01-03 Created: 2011-01-03 Last updated: 2017-12-11Bibliographically approved

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Stavreus-Evers, Anneli

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