uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Prostate cancer risk in the Swedish AMORIS study: the interplay among triglycerides, total cholesterol, and glucose
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
Show others and affiliations
2011 (English)In: Cancer, ISSN 0008-543X, E-ISSN 1097-0142, Vol. 117, no 10, 2086-2095 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: In a cohort including 5112 prostate cancer (pCa) patients, the authors investigated associations among triglycerides (TG), total cholesterol (TC), and pCa while taking into account glucose. METHODS: A cohort (n = 200,660) based on 4 groups of men, according to age at cohort entry, with TG, TC, and glucose measurements was selected from the Apolipoprotein MOrtality RISk (AMORIS) database. Of these, 5112 men developed pCa. Multivariate Cox proportional hazard models were used to analyze associations among TG, TC, and pCa. Competing risks were assessed graphically. RESULTS: Age-stratified analyses for quartiles of TG, TC, and glucose showed a negative association between glucose and pCa risk (HR, 0.93; 95% CI, 0.86-1.01), 0.93 (0.86-1.01), 0.87 (0.81-0.94) for the second, third, and fourth quartiles compared with the first (P-trend = .001). Stratified analysis by glucose levels (< 6.11 or >= 6.11 mmol/L) showed a positive association between hypertriglyceridemia (TG >= 1.71 mmol/L) and pCa risk, when there were high glucose levels (HR, 1.23; 95% CI, 1.01-1.48). No association was found for hypercholesterolemia (TC >= 6.50 mmol/L). Competing risk analysis showed that protective effects of glucose were overestimated in conventional Cox proportional hazard models and strengthened positive findings between TG and pCa risk. CONCLUSIONS: The authors' findings supported the hypothesis that factors of the glucose and lipid metabolism influence pCa risk. Competing risk assessment showed that it is important to take into account the long natural history and age distribution of pCa when interpreting results. The authors' findings indicate another reason to fight the increasing prevalence of obesity and dyslipidemia.

Place, publisher, year, edition, pages
2011. Vol. 117, no 10, 2086-2095 p.
Keyword [en]
prostate cancer, total cholesterol, triglycerides, glucose, hypercholesterolemia, hypertriglyceridemia
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-140119DOI: 10.1002/cncr.25758ISI: 000290161100009PubMedID: 21117226OAI: oai:DiVA.org:uu-140119DiVA: diva2:383059
Available from: 2011-01-04 Created: 2011-01-04 Last updated: 2012-05-14Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Holmberg, Lars
By organisation
Endocrine Surgery
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 181 hits
ReferencesLink to record
Permanent link

Direct link