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Expression of peripherin in human cochlea
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2010 (English)In: Cell and Tissue Research, ISSN 0302-766X, E-ISSN 1432-0878, Vol. 342, no 3, 345-351 p.Article in journal (Refereed) Published
Abstract [en]

The organ of Corti contains two different types of auditory receptors; the inner (IHCs) and outer (OHCs) hair cells. This dualism is further represented in their innervation, IHCs being innervated by type I neurons, and OHCs by type II neurons (in man, named small ganglion cells). Two efferent systems are also present. Here, we have analyzed the expression of the 57-kDa neuron-specific intermediate filament protein peripherin (PP) in human cochlea. In the human organ of Corti, PP seems to be specifically expressed in OHC afferents. Small or type II spiral ganglion cell bodies also intensely express PP. Thus, PP can be used as a marker for the characterization of the innervation of the OHC system in man.

Place, publisher, year, edition, pages
2010. Vol. 342, no 3, 345-351 p.
Keyword [en]
Spiral ganglion, Inner ear, Peripherin, Outer hair cells, Innervation, Human
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-140161DOI: 10.1007/s00441-010-1081-6ISI: 000284956700004PubMedID: 21088854OAI: oai:DiVA.org:uu-140161DiVA: diva2:383095
Available from: 2011-01-04 Created: 2011-01-04 Last updated: 2017-12-11Bibliographically approved

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Liu, WeiBoström, MarjaRask-Andersen, Helge

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