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To polyadenylate or to deadenylate: That is the question
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2010 (English)In: Cell Cycle, ISSN 1538-4101, E-ISSN 1551-4005, Vol. 9, no 22, 4437-4449 p.Article in journal (Refereed) Published
Abstract [en]

Messenger RNA polyadenylation and deadenylation are important processes that allow rapid regulation of gene expression in response to different cellular conditions. Almost all eukaryotic mRNA precursors undergo a co-transcriptional cleavage followed by polyadenylation at the 3' end. After the signals are selected, polyadenylation occurs to full extent, suggesting that this first round of polyadenylation is a default modification for most mRNAs. However, the length of these poly(A) tails changes by the activation of deadenylation, which might regulate gene expression by affecting mRNA stability, mRNA transport or translation initiation. The mechanisms behind deadenylation activation are highly regulated and associated with cellular conditions such as development, mRNA surveillance, DNA damage response, cell differentiation and cancer. After deadenylation, depending on the cellular response, some mRNAs might undergo an extension of the poly(A) tail or degradation. The polyadenylation/deadenylation machinery itself, miRNAs or RNA binding factors are involved in the regulation of polyadenylation/deadenylation. Here, we review the mechanistic connections between polyadenylation and deadenylation and how the two processes are regulated in different cellular conditions. It is our conviction that further studies of the interplay between polyadenylation and deadenylation will provide critical information required for a mechanistic understanding of several diseases, including cancer development.

Place, publisher, year, edition, pages
2010. Vol. 9, no 22, 4437-4449 p.
Keyword [en]
polyadenylation, deadenylation, 3 ' end processing, mRNA steady state levels, mRNA surveillance, cell differentiation processes, DNA damage, exosome, AU-rich element, miRNA
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-140160DOI: 10.4161/cc.9.22.13887ISI: 000285002800013OAI: oai:DiVA.org:uu-140160DiVA: diva2:383096
Available from: 2011-01-04 Created: 2011-01-04 Last updated: 2011-01-04Bibliographically approved

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