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Resveratrol regulates the expression of LXR-alpha in human macrophages
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
2006 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 348, no 3, 1047-1054 p.Article in journal (Refereed) Published
Abstract [en]

The naturally occurring polyphenol resveratrol has been associated with the beneficial effects of red wine consumption on cardiovascular disease and shown to inhibit atherosclerosis in animal models. To determine if resveratrol affects the expression of genes that control lipid homeostasis in human macrophages, we measured expression changes in the LXR-alpha pathway, crucial to cholesterol efflux, and in genes that mediate lipoprotein uptake. Resveratrol treatment of THP-1 macrophages induced LXR-alpha at mRNA and protein levels. Increased recruitment of RNA polymerase 11 to the LXR-alpha promoter suggested that up-regulation was at least partly mediated by transcriptional mechanisms. Resveratrol also induced LXR-alpha in human monocyte-derived macrophages together with elevated ABCAI and ABCGI mRNA levels. Moreover, resveratrol repressed the expression of the lipid uptake genes LPL and SR-All. The ability of resveratrol to modulate expression of the genes involved in lipid uptake and efflux suggests that polyphenols can potentially limit cholesterol accumulation in human macrophages.

Place, publisher, year, edition, pages
2006. Vol. 348, no 3, 1047-1054 p.
Keyword [en]
LXR-alpha, THP-1, macrophages, resveratrol, chromatin immunoprecipitation, gene regulation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-10546DOI: 10.1016/j.bbrc.2006.07.155ISI: 000240166500037PubMedID: 16901463OAI: oai:DiVA.org:uu-10546DiVA: diva2:38314
Available from: 2007-04-02 Created: 2007-04-02 Last updated: 2011-06-20Bibliographically approved

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Sevov, MarieElfineh, LioudmilaCavelier, Lucia B.

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