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Limited knowledge on progestogen-only contraception and risk of venous thromboembolism
Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Internationell kvinno- & mödrahälsovård/Essén)
Medical Products Agency, Uppsala, Sweden.
Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden.
2009 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 88, no 3, p. 261-266Article, review/survey (Refereed) Published
Abstract [en]

Objective. To assess the current knowledge concerning progestogen-only contraception (POC) and risks of venous thromboembolism (VTE). Design and setting. Systematic review of the literature on observational and analytical studies reporting risk estimates for VTE in women exposed to POCs. Methods and main outcome measures. We performed a computerized literature search in the Pub Med, Embase, and the Cochrane Library for studies published between 1966 and February 13, 2008. Based on the evaluated studies we calculated an overall risk estimate for VTE in association with POC. Results. Four case-control studies and one cohort study were included. Of the case-control studies, three reported an increased risk and one a decreased risk of VTE. The cohort study found divergent results depending on the type of statistical analysis used. None of the results was statistically significant. The overall odds ratio for POC-associated VTE in the four case-control studies was 1.45 (95% CI=0.92-2.26). Conclusions. The risk of VTE associated with use of POCs is poorly investigated. The slightly elevated overall risk estimate might suggest an association between POC and an increased risk for VTE. The results must, however, be interpreted with caution due to the possibility of residual confounding. Well-designed studies with sufficient statistical power to evaluate risks of VTE with POC are warranted.

Place, publisher, year, edition, pages
2009. Vol. 88, no 3, p. 261-266
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-140278DOI: 10.1080/00016340902730375ISI: 000263704300005PubMedID: 19172422OAI: oai:DiVA.org:uu-140278DiVA, id: diva2:383363
Available from: 2011-01-04 Created: 2011-01-04 Last updated: 2017-12-11Bibliographically approved

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