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Expression of connective tissue growth factor and IGF1 in normal and neoplastic gastrointestinal neuroendocrine cells and their clinico-pathological significance
Department of Pathophysiology, National University of Athens, Athens 11527, Greece..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Endocrine Oncology)
Department of Clinical Pathology and Cytology, the Ryhov County Hospital, Jönköping, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular and Morphological Pathology. (Endocrine Pathology)
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2011 (English)In: Endocrine-Related Cancer, ISSN 1351-0088, E-ISSN 1479-6821, Vol. 18, no 1, 61-71 p.Article in journal (Refereed) Published
Abstract [en]

Connective tissue growth factor (CTGF) and IGF1 are both expressed in a variety of tumours and are involved in tumourigenesis. However, information about their expression in the gastrointestinal (GI) neuroendocrine (NE) cells and tumours is mainly limited, with the exception of midgut carcinoids where abundant CTGF expression has been demonstrated. Normal mucosa specimens from stomach and ileum, as well as tumour tissue specimens from gastric NE tumours (GNETs; n=58) and midgut NETs (n=38) were included. Immunohistochemical techniques were used to investigate the possible expression of CTGF and IGF1 in GI NE cells and tumours. The latter results were correlated with various clinico-biochemical and histopathological variables. CTGF was expressed in a proportion of NE cells of the normal GI mucosa but not in enterochromaffin-like (ECL) cells, whereas IGF1 was undetectable. CTGF was absent in the foci of ECL cell hyperplasia, and in most of the poorly differentiated carcinomas, but present in some GNETs (mainly in type III ECL cell carcinoids (ECL-CCs)) and in all but one midgut NETs. CTGF correlated with tumour stage in well-differentiated GNETs and with size larger than 1  cm but only in the subgroup of type I ECL-CCs. IGF1 was detected in the foci of ECL cell hyperplasia and in all GI NETs. These findings suggest that both CTGF and IGF1 may be involved in the neoplastic transformation of GI NE cells, whereas IGF1 may play an important role even at early stage.

Place, publisher, year, edition, pages
Uppsala: Uppsala University , 2011. Vol. 18, no 1, 61-71 p.
Keyword [en]
Connective tissue growth factor, Insulin growth factor 1
National Category
Gastroenterology and Hepatology Cancer and Oncology
Research subject
URN: urn:nbn:se:uu:diva-140366DOI: 10.1677/ERC-10-0026ISI: 000208798400009PubMedID: 20959439OAI: oai:DiVA.org:uu-140366DiVA: diva2:383491
Available from: 2011-01-05 Created: 2011-01-05 Last updated: 2015-07-23Bibliographically approved

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Tsolakis, Apostolos
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