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Argentine population genetic structure: large variance in Amerindian contribution
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2007 (English)In: American Journal of Physical Anthropology, ISSN 0002-9483, E-ISSN 1096-8644, Vol. 132, no 3, 455-462 p.Article in journal (Refereed) Published
Abstract [en]

Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies.

Place, publisher, year, edition, pages
2007. Vol. 132, no 3, 455-462 p.
Keyword [en]
Admixture, Ancestry informative markers, Population stratification
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-10593DOI: 10.1002/ajpa.20534ISI: 000244171200010PubMedID: 17177183OAI: oai:DiVA.org:uu-10593DiVA: diva2:38361
Available from: 2008-05-29 Created: 2008-05-29 Last updated: 2017-12-11Bibliographically approved

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Alarcon-Riquelme, Marta E.

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