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Patients with polycystic ovary syndrome have lower levels of IgM anti-phosphorylcholine antibodies than healthy women
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Reproduktiv hälsa/Sundström Poromaa)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Allmänpediatrisk forskning/Nordvall)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Reproduktiv hälsa/Sundström Poromaa)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Reproduktiv hälsa/Sundström Poromaa)
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2011 (English)In: Gynecological Endocrinology, ISSN 0951-3590, E-ISSN 1473-0766, Vol. 27, no 7, 486-490 p.Article in journal (Refereed) Published
Abstract [en]

Introduction. IgM antibodies against phosphorylcholine (IgM anti-PC) are natural autoantibodies, possibly exerting one of the atheroprotective functions of the immune system. Increased levels of these antibodies reduce the development of atherosclerosis in mice, and low levels of IgM anti-PC have been associated with increased risk for cardiovascular disease (CVD). This study compared levels of IgM anti-PC in women with polycystic ovary syndrome (PCOS, n = 111) and healthy controls (n = 79). Method. Levels of IgM anti-PC were measured with ELISA. Results. The median level of IgM anti-PC in patients with PCOS was not significantly different compared to control subjects. However, the proportion of patients with PCOS with low levels of IgM anti-PC, defined as number of individuals below the median level, was significantly higher than among healthy controls, p < 0.05. Patients with PCOS in the oldest age quintile had significantly lower level of IgM anti-PC than control subjects of similar age (p < 0.05) and younger women with PCOS (p < 0.01). Conclusion. Our results indicate that women with PCOS more frequently display below-median levels of IgM anti-PC than controls and older women with PCOS have lower median anti-PC levels. Further studies of how this finding translates into actual CVD risk in women with PCOS are needed.

Place, publisher, year, edition, pages
2011. Vol. 27, no 7, 486-490 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-140555DOI: 10.3109/09513590.2010.501880ISI: 000291221600007PubMedID: 20645890OAI: oai:DiVA.org:uu-140555DiVA: diva2:383771
Available from: 2011-01-05 Created: 2011-01-05 Last updated: 2017-12-11Bibliographically approved

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Gingnell, MalinDahlbom, IngridLindholm, ÅsaHudecova, MiriamArnadottir, RagnheidurHansson, TonySundström-Poromaa, Inger

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Gingnell, MalinDahlbom, IngridLindholm, ÅsaHudecova, MiriamArnadottir, RagnheidurHansson, TonySundström-Poromaa, Inger
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