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Characterization of a Trypanosoma cruzi acetyltransferase: cellular location, activity and structure
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology. (Åslund)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
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2007 (English)In: Molecular and biochemical parasitology (Print), ISSN 0166-6851, E-ISSN 1872-9428, Vol. 152, no 2, 123-131 p.Article in journal (Refereed) Published
Abstract [en]

Trypanosomatids are widespread parasites that cause three major tropical diseases. In trypanosomatids, as in most other organisms, acetylation is a common protein modification that is important in multiple, diverse processes. This paper describes a new member of the Trypanosoma cruzi acetyltransferase family. The gene is single copy and orthologs are also present in the other two sequenced trypanosomatids, Trypanosoma brucei and Leishmania major. This protein (TcAT-1) has the essential motifs present in members of the GCN5-related acetyltransferase (GNAT) family, as well as an additional motif also found in some enzymes from plant and animal species. The protein is evolutionarily more closely related to this group of enzymes than to histone acetyltransferases. The native protein has a cytosolic cellular location and is present in all three life-cycle stages of the parasite. The recombinant protein was shown to have autoacetylation enzymatic activity.

Place, publisher, year, edition, pages
2007. Vol. 152, no 2, 123-131 p.
Keyword [en]
Acetyltransferase, Trypanosoma cruzi, Autoacetylation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-10666DOI: 10.1016/j.molbiopara.2006.12.009ISI: 000245318900002PubMedID: 17270289OAI: oai:DiVA.org:uu-10666DiVA: diva2:38434
Available from: 2007-11-27 Created: 2007-11-27 Last updated: 2011-04-07Bibliographically approved

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Respuela, PatriciaÅslund, Lena

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