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Basic aspects of exhaled nitric oxide
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. (Allmänpediatrisk forskning/ Nordvall)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
2010 (English)In: European Respiratory Monograph, ISSN 1025-448X, E-ISSN 2075-6674, Vol. 49, 1-31 p.Article, review/survey (Refereed) Published
Abstract [en]

Nitric oxide (NO) in orally exhaled air mainly originates fromthe respiratory epithelium. NO is produced by inducible NOsynthase (iNOS), which is regulated by signal transducer andactivator of transcription (STAT)-1 under the influence ofhomeostatic interferon-c. In patients with asthma, iNOSexpression is upregulated by interleukin (IL)-4 and IL-13 viathe activation of STAT-6 in the bronchial epithelium. Thus,exhaled NO primarily signals local T-helper cell type 2-driveninflammation in the bronchial mucosa. With these character-istics, exhaled NO will be a suitable marker for predicting theresponse to inhaled corticosteroids, and to monitor the anti-inflammatory effect.The methodology for measuring exhaled NO has beenstandardised based on international consensus. The determi-nants of exhaled NO levels are fairly well characterised, withthe most important being cigarette smoking, nitrate intake, airpollution, allergen sensitisation and exposure, along withheight, sex and age. A future development may be the estima-tion of peripheral airway inflammation by measuring exhaledNO at multiple exhalation flow rates.

Place, publisher, year, edition, pages
2010. Vol. 49, 1-31 p.
Keyword [en]
Asthma, breath test, eosinophil, epithelium, nitric oxide, signal transducer and activator of transcription-6
National Category
Clinical Medicine
URN: urn:nbn:se:uu:diva-140836DOI: 10.1183/1025448x.00028509OAI: oai:DiVA.org:uu-140836DiVA: diva2:384488
Available from: 2011-01-10 Created: 2011-01-10 Last updated: 2014-09-23Bibliographically approved

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Alving, KjellMalinovschi, Andrei
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