A large-scale, consortium-based genomewide association study of asthma
2010 (English)In: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 363, no 13, 1211-1221 p.Article in journal (Refereed) Published
Asthma is genetically heterogeneous. A few common alleles are associated with disease risk at all ages. Implicated genes suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation. Variants at the ORMDL3/GSDMB locus are associated only with childhood-onset disease. Elevation of total serum IgE levels has a minor role in the development of asthma.
Place, publisher, year, edition, pages
2010. Vol. 363, no 13, 1211-1221 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-140861DOI: 10.1056/NEJMoa0906312ISI: 000282050000005PubMedID: 20860503OAI: oai:DiVA.org:uu-140861DiVA: diva2:384530
Co-author, the GABRIEL Consortium: Christer Janson, Uppsala universitet, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.2011-01-102011-01-102016-10-03Bibliographically approved