uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
A large-scale, consortium-based genomewide association study of asthma
Show others and affiliations
2010 (English)In: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 363, no 13, 1211-1221 p.Article in journal (Refereed) Published
Abstract [en]

Asthma is genetically heterogeneous. A few common alleles are associated with disease risk at all ages. Implicated genes suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation. Variants at the ORMDL3/GSDMB locus are associated only with childhood-onset disease. Elevation of total serum IgE levels has a minor role in the development of asthma.

Place, publisher, year, edition, pages
2010. Vol. 363, no 13, 1211-1221 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-140861DOI: 10.1056/NEJMoa0906312ISI: 000282050000005PubMedID: 20860503OAI: oai:DiVA.org:uu-140861DiVA: diva2:384530

Co-author, the GABRIEL Consortium: Christer Janson, Uppsala universitet, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.

Available from: 2011-01-10 Created: 2011-01-10 Last updated: 2016-10-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Janson, Christer
By organisation
Respiratory Medicine and Allergology
In the same journal
New England Journal of Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 195 hits
ReferencesLink to record
Permanent link

Direct link